Pathogenesis Of Coronavirus
The molecular mechanisms of replication as well as the pathogenesis of several coronaviruses have been actively studied since the 1970s. Middle east respiratory syndrome coronavirus mers cov is a causative agent of severe to fatal pneumonia especially in patients with pre existing conditions such as smoking and chronic.
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The isolation of the prototype murine coronavirus strain jhm for example was reported in 1949 7 41.
Pathogenesis of coronavirus. The much publicized human coronavirus discovered in 2003 sars cov which causes severe acute respiratory syndrome sars has a unique pathogenesis because it causes both upper and lower respiratory tract infections. Coronaviruses infect many species of animals including humans causing acute and chronic diseases. This review focuses primarily on the pathogenesis of murine coronavirus mouse hepatitis virus mhv and severe acute respiratory coronavirus sars cov. Coronaviruses have been described for more than 50 years. However further insight into the pathogenesis and pathological potential of merscov may be obtained by comparing and contrasting the epidemiology clinical manifestations and host cell response of merscov to infection with sarscov which may also cause a lifethreatening lower respiratory tract disease. Coronaviruses infect many species of animals including humans causing acute and chronic diseases. This review focuses primarily on the pathogenesis of murine coronavirus mouse hepatitis virus.
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